Intrasvascular Hemolysis Secondary to Clostridium perfringens Septicemia in the Setting of Febrile Neutropenia: A Case Report and Review of the Literature
CCCF ePoster library. Basmaji J. Oct 26, 2015; 117348; P33
John Basmaji
John Basmaji
Login now to access Regular content available to all registered users.

You may also access this content "anytime, anywhere" with the Free MULTILEARNING App for iOS and Android
Abstract
Rate & Comment (0)
P33


Topic: Case Report


Intrasvascular Hemolysis Secondary to Clostridium perfringens Septicemia in the Setting of Febrile Neutropenia: A Case Report and Review of the Literature



John Basmaji, F. Myslik, M. Keeney, M. Slessarev

Critical Care Medicine, London Health Science Centre, London, Canada | Critical Care Medicine, London Health Science Centre, London, Canada | Hematology, London Health Science Centre, London, Canada | Critical Care Medicine, London Health Science Centre, London, Canada

Introduction:

Infection by Clostridium perfringens has a wide spectrum of clinical presentations, with intravascular hemolysis being both a hallmark feature and a life-threatening complication. Traditionally, this rare condition has been associated with invasive manipulation of hepatobiliary, intestinal or gynecological foci.



Objectives: 1) To present a case of C. perfringens septicaemia in the context of febrile neutropenia. 2) To review the literature and discuss the causes and management strategies for C. perfringens septicaemia. 3) To shed light on the rare but fatal complication of massive intravascular hemolysis associated with C. perfringens septicaemia.




Methods:

Consent was obtained from the family’s next of kin. A retrospective review of the medical records was undertaken.



Results:

We present a case of a patient who was admitted to our intensive care unit with febrile neutropenia, septic shock and hemolysis of unknown etiology. The patient had no recent history of invasive abdominal or pelvic procedures. Blood cultures grew C. perfringens. Images of the peripheral blood smear highlighting the features of intravascular hemolysis caused by C. perfringens are shown. We present a review of the literature with a specific focus on the causes and management of C. perfringens sepsis.



Conclusion:

In critically ill patients who present to the intensive care unit with sepsis and intravascular hemolysis, C. perfringens septicemia should be considered early to maximize overall survival through prompt antibiotic administration, source control, and optimization of oxygen delivery.



References: N/A.
    This eLearning portal is powered by:
    This eLearning portal is powered by MULTIEPORTAL
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.


Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.


Save Settings