Evaluating serum albumin as a marker of volume status and inflammation in septic intensive care unit (ICU) patients: a prospective observational study
CCCF ePoster library. Pop P. Nov 1, 2016; 150967; 86
Paula Pop
Paula Pop
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Topic: Retrospective or Prospective Cohort Study

Evaluating serum albumin as a marker of volume status and inflammation in septic intensive care unit (ICU) patients: a prospective observational study

Pop, Paula; Lalji; Faraz; Rochwerg, Bram1; Cheung, Jason H1; Ribic, Christine M.1,2,3; Margetts, Peter J.1,3; Gangji, Azim S.1,3  

1Department of Medicine, McMaster University, Hamilton, Canada

2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada

3Division of Nephrology, St Joseph’s Healthcare Hamilton, Hamilton, Canada 

Grant acknowledgements:
Financial Support for the Study: Canadian Institute of Health Research – 2014-2015 Health Professional Student Research Award


Introduction: Serum albumin is an important protein for maintaining intravascular volume. Albumin also acts as a negative acute phase reactant which declines during sepsis.
Objective: We sought to determine the relationship between serum albumin and markers of volume status and inflammation in intensive care unit (ICU) patients with sepsis.
Method: This was a prospective observational multi-center study. Our primary outcome was to determine if an association existed between serum albumin and markers of volume status(Bioimpedance analysis (BIA) derived vector length (VL) and N-terminal brain natriuretic peptide (N-BNP)) and markers of inflammation (C-reactive protein (CRP), interleukin (IL)-6, IL-8, and IL-10). Correlation was assessed using Spearman’s rho.   
Results: 30 patients were enrolled. Serum albumin correlated with CRP (r = -0.39, p = 0.04) and IL-12 (r = 0.50, p = 0.01). Serum albumin did not correlate with n-BNP (r = 0.02, p = 0.91) or BIA derived VL (r = 0.3, p = 0.11). However, BIA derived VL did correlated with GM-CSF (r = 0.41, p = 0.03), IL-6 (r = -0.41, p = 0.03), IL-10 (r = -0.38, p = 0.04).
Conclusion: Based on our findings, serum albumin is primarily a marker of inflammation as opposed to volume status. Volume overload states are associated with elevated inflammatory markers.  .Our study findings are limited by a small sample size and further assessment of the above findings is warranted in a larger prospective observational study.

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