Comparison Between Dexmedetomidine, Midazolam and Propofol For Sedation in Mechanically Ventilated Intensive Care Patients
CCCF ePoster library. Rahimzadeh P. Oct 3, 2017; 198134; 10 Disclosure(s): Nothing to declare
Dr. Poupak Rahimzadeh
Dr. Poupak Rahimzadeh
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Comparison Between Dexmedetomidine, Midazolam and Propofol For Sedation in Mechanically Ventilated Intensive Care Patients

Poupak Rahimzadeh1

Seyed Hamid Reza Faiz1

1-Associate Professor of Anesthesiology, Departement of Anesthesiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran


Patients on ventilatory support in intensive care unit (ICU) require sedation and analgesia to facilitate mechanical ventilation and endotracheal tube tolerance. Clinical outcomes such as heart rate and blood pressure may be improved with dexmedetomidine as compared with benzodiazepines and propofol in studies. The objective of this study was to determine the clinical effectiveness of a sedation infusion protocol for dexmedetomidine.
A total of 90 adult, mechanically ventilated patients meeting the standard criteria for weaning, randomized into 3 groups of 30 patients each, received intravenous infusion of dexmedetomidine (0.2-0.7 mcg/kg/h)(DG) or midazolam (0.04-0.2 mg/kg/h)(MG) or propofol ( 1-3mg/kg/hr) (PG) as needed for Ramsay sedation scale 2-4. Extubation performed following with standard extubation. Time for extubation and vital parameters were regularly recorded.
The time to extubation in the DG was essentially lower than the other groups. Heart rate and blood pressure was essentially lower in DG than the other groups at the majority of the circumstances.
Dexmedetomidine has clinically significant advantages in facilitating extubation due to its shorter time to extubation, more hemodynamic stability, and absence of respiratory depression.

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