Impact of Streptococcus pneumoniae Colonization in Critically Ill Children with Viral Bronchiolitis
CCCF ePoster library. Genise K. Oct 2, 2017; 198161; 9
Kira Genise
Kira Genise
Login now to access Regular content available to all registered users.

You may also access this content "anytime, anywhere" with the Free MULTILEARNING App for iOS and Android
Rate & Comment (0)

Impact of Streptococcus Pneumoniae colonization in Viral Bronchiolitis

Genise, Kira1; Srinivas, Murthy.2 

1 University of Ottawa, Ottawa, Ontario, Canada

2 Critical Care Unit, BC Children's Hospital, Vancouver, Canada

Introduction: Viral bronchiolitis is one of the most prevalent causes of illness requiring hospitalization among children worldwide1 and one of the most common reasons for admission to pediatric intensive care. It has been hypothesized that co-infection with bacteria results in more severe clinical outcomes. However, the effects of bacterial colonization, affecting upwards of 15% of healthy children2, on critically ill patients with bronchiolitis have yet to be proven. Current clinical management consists primarily of supportive therapies with the role of antibiotics remaining controversial.3
Objectives/Methods: A retrospective review of all critically ill children admitted to the BC Children’s Hospital Pediatric Intensive Care Unit (PICU) from 2014-2017 with a diagnosis of bronchiolitis was performed.  Routine testing in this timeframe consisted of complete pathogen testing, including PCR for Streptococcus pneumoniae. Analyses were performed to determine the impact of bacterial colonization and antibiotic use on a primary outcome of PICU length-of-stay, with secondary outcomes of hospital stay and duration of ventilation.
Results: There were 92 patients with complete pathogen testing performed during the assessed timeframe. A comparison between children with detected Streptococcus pneumoniae (n=22) and those without (n=70) revealed no significant (p=0.20) differences in severity of illness on presentation as per PRISM III scores (mean=3.0). Patients colonized with S. pneumoniae had significantly shorter PICU stays (p=0.002), hospital stays (p=0.0001) and duration of non-invasive ventilation (p=0.002). Multivariate analyses reveals that these effects on length of PICU stay and duration of ventilation do not persist after controlling for antibiotic use, presence of radiographic consolidation, age, and severity of illness (p=0.15, p=0.32). The relationship between colonization and duration of hospital stay persists after controlling for these variables (p=0.008).
Conclusions: Children with viral bronchiolitis colonized with S. pneumoniae appear to have shorter hospital stays but similar length of PICU stays and duration of ventilation compared to children who are not colonized. Consistent with current literature4, the results of this study suggest bacterial colonization is not associated with increased severity of presenting illness or negative clinical outcomes. 

    This eLearning portal is powered by:
    This eLearning portal is powered by MULTIEPORTAL
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.

Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.

Save Settings